Cryptococcus neoformans Capsular Enlargement and Cellular Gigantism during Galleria mellonella Infection
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چکیده
منابع مشابه
Cryptococcus neoformans Capsular Enlargement and Cellular Gigantism during Galleria mellonella Infection
We have studied infection of Cryptococcus neoformans in the non-vertebrate host Galleria mellonella with particular interest in the morphological response of the yeast. Inoculation of C. neoformans in caterpillars induced a capsule-independent increase in haemocyte density 2 h after infection. C. neoformans manifested a significant increase in capsule size after inoculation into the caterpillar...
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A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is a consistent increase in capsule volume. Given that many aspects of the interaction of C. neoformans with macrophages are also observed with amoebae, we hypothesized that the capsule enlargement phenomenon also had a protozoan parallel. Incubation of C. neoformans with Acanthamoeba castellanii resulted in ...
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Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that ...
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EditoriAL Pathogens and their respective hosts interact closely leading to the host–pathogen framework response that could result in different outcomes that range from pathogen elimination to death of the host. To improve our ability to propose new measures that promote pathogen elimination and prevent host death, we need to have a comprehensive understanding of this interaction. Generally , mo...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0024485